NFL Draft Kings Lineup Advice for Week Two 2025

Daily Fantasy Football on DraftKings is all about balancing star power with value plays, finding matchups to exploit, and piecing together a roster that can hit its ceiling when it matters most. For Week Two of the 2025 NFL season, the lineup pictured above comes in right at the $50,000 salary cap, with a nice mix of proven studs, breakout candidates, and a budget-friendly defense. Let’s dive into each position and break down why these picks make sense.


Quarterback: Josh Allen – $7,100 (vs. Jets)

Josh Allen continues to be one of the most bankable options in DFS. At $7,100, he’s priced below Patrick Mahomes and Lamar Jackson, yet his ceiling is just as high. Allen’s Week One performance showed he’s still the focal point of the Bills’ offense, racking up 41.8 DraftKings points. Facing the Jets in Week Two, he’ll see a tough defense, but Allen’s rushing ability and penchant for big plays make him a safe anchor for any lineup. Even if the Jets force him into mistakes, his dual-threat nature ensures fantasy production.


Running Back 1: Breece Hall – $6,200 (vs. Bills)

Pairing Hall against Allen in the same game creates an interesting game-script hedge. If the Bills jump ahead, Hall will be heavily involved as a pass catcher. If the Jets control the tempo, Hall is the centerpiece of their ground attack. At $6,200, he’s priced reasonably for a back averaging 19.5 fantasy points per game. Hall’s explosiveness makes him capable of breaking off a slate-breaking run, and the Bills’ defense can be vulnerable against versatile backs.


Running Back 2: Javonte Williams – $5,800 (vs. Cowboys)

Javonte Williams has shaken off his past injuries and looks like a volume play in 2025. With 20.4 FPPG through Week One, he’s returning excellent value for under $6,000. Against a Cowboys defense that sometimes sells out to stop the pass, Williams could thrive between the tackles. His usage in the passing game also makes him a strong PPR option, boosting his DraftKings appeal.


Wide Receiver 1: Michael Pittman Jr. – $5,100 (vs. Broncos)

Pittman at just $5,100 is a steal. He’s already averaging 20 fantasy points per game, and as the Colts’ primary target, his floor is extremely stable. Facing Denver, Pittman might draw some tough coverage, but his target share ensures he’s worth the investment. In DFS, volume is king, and Pittman’s chemistry with his quarterback makes him a budget-friendly WR1 for this lineup.


Wide Receiver 2: Keon Coleman – $5,100 (vs. Jets)

Stacking Allen with Keon Coleman is a sharp DFS strategy. Coleman has emerged as a go-to red zone target and is averaging 28.2 fantasy points per game early in the season. With defenses keying on Stefon Diggs, Coleman benefits from favorable coverage and Allen’s trust in key moments. This stack maximizes the upside—if Allen has a big game, Coleman likely does too.


Wide Receiver 3: Rome Odunze – $4,800 (vs. Lions)

Rome Odunze represents the perfect value pick in this lineup. At just $4,800, he brings a 15.7 FPPG average and continues to carve out a significant role in the Bears’ offense. Against the Lions in a likely high-scoring divisional matchup, Odunze could benefit from game flow and see plenty of opportunities. He rounds out the receiver corps with upside at a discount.


Tight End: Travis Kelce – $5,000 (vs. Eagles)

Kelce at $5,000 feels like a discount given his history as a consistent DFS stud. His Week One output of 12.7 points isn’t spectacular, but his ceiling is always immense, especially in a marquee matchup against the Eagles. Philadelphia’s secondary is stronger than its linebacker coverage, making Kelce a logical target funnel for Patrick Mahomes. The price point allows you to roster a potential slate-breaker at tight end without crippling your cap.


Flex: Derrick Henry – $8,200 (vs. Ravens)

The biggest spend of the lineup comes in the flex with Derrick Henry, and for good reason. At 33.2 FPPG in Week One, Henry proved he’s still “King Henry.” Facing a Ravens defense that can struggle with power backs, Henry provides massive upside. The flex spot is often best used for a running back with high volume, and Henry fits the bill as the focal point of Tennessee’s offense. His potential for multiple touchdowns makes him a must-have despite the hefty salary.


Defense/Special Teams: Titans – $2,400 (vs. Rams)

Saving salary at defense is a common DFS strategy, and the Titans at $2,400 open up cap space for stars like Henry and Allen. While Tennessee’s defense doesn’t project as elite, they’re serviceable against a Rams offense that remains inconsistent. All you need from a budget defense is a few sacks, turnovers, or maybe a lucky touchdown. At this price, the Titans are a fine punt play.


Final Thoughts

This lineup balances high-upside stars with affordable role players. The Josh Allen–Keon Coleman stack offers slate-breaking potential, while Derrick Henry provides a power-floor in the flex. Value picks like Rome Odunze and Michael Pittman Jr. allow the salary to stretch without sacrificing production. By punting defense, the roster maximizes exposure to offensive playmakers.